
Independence was the farthest point westward on the Missouri River where the steamboats or other cargo vessels could travel, due to the convergence of the Kansas River with the Missouri River approximately six miles west of town, near the current Kansas-Missouri border. Named after the Declaration of Independence, Independence was founded on March 29, 1827, and quickly became an important frontier town. Independence was also a stopping point for the " Donner Party", an ill fated group of 19th Century wagon train emigrants whose westward journey along the California Trail ended in disaster spawning one of the most well known and taboo stories of pioneer era America. Lewis and Clark recorded in their journals that they stopped in 1804 to pick plums, raspberries, and wild apples at a site that would later form part of the city.

It became part of the United States with the Louisiana Purchase in 1803. Independence was originally inhabited by Missouri and Osage Native Americans, followed by the Spanish and a brief French tenure. The city is sacred to the Latter Day Saint movement, as the home of Joseph Smith's 1831 Temple Lot, and the headquarters of several Mormon denominations. Truman, with the Truman Presidential Library and Museum, and the gravesites of Truman and First Lady Bess Truman. Independence is known as the "Queen City of the Trails" because it was a point of departure for the California, Oregon, and Santa Fe Trails.

In 2020, it had a total population of 123,011.

Independence is a satellite city of Kansas City, Missouri, and is the largest suburb on the Missouri side of the Kansas City metropolitan area.

Independence is the fifth-largest city in Missouri and the county seat of Jackson County.
